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Drug Name


Plendil (Felodipine)
Drug Uses


Plendil is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Felodipine is known as a calcium channel blocker. By blocking calcium, this medication relaxes and widens blood vessels so blood can flow more easily. 
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Take this medication by mouth usually once a day on an empty stomach, or as directed by your doctor. If stomach upset occurs, Plendil may be taken with a light meal. Dosage is based on your medical condition and response to therapy. Swallow this medication whole. Do not crush, chew, or break the tablets, which can destroy the long action of the drug and increase side effects. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. This drug is not effective if you use it only when chest pain occurs. It is very important to take this medication regularly as prescribed to help prevent chest pain. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit juice can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased. 
Drug Class and Mechanism


Plendil is an oral calcium- channel blocker (CCB) of the dihydropyridine (DHP) class. Other calcium channel blockers in the DHP class include nifedipine (Procardia, Adalat), amlodipine (Norvasc), nisoldipine (Sular), nicardipine (Cardene), and isradipine (Dynacirc). Calcium is necessary for muscle cells to contract. Plendil prevents calcium from being released within the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to dilate or expand. Plendil has little or no effect on the muscles of veins or the heart . Plendil was approved by the FDA in 1991. 
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